Diabetes Mellitus As A Chronic Metabolic Disorder Essay

Chapter - 23 Diabetes Diabetes Mellitus is a chronic metabolic disorder that prevents the body to utilise glucose completely or partially. It is characterised by raised glucose concentration in the blood and alterations in carbohydrate, protein and fat metabolism. This can be due to failure in the formation of insulin or liberation or action. Since insulin is produced by the p cells of the islets of Langerhans, any receding in the number of functioning cells will decrease the amount of insulin that can be synthesised. Many diabetics can produce sufficient insulin but some stimulus to the islets tissue is needed in order that secretion can take place. During the early stages of the disease, the Insulin Like Activity (ILA) of the blood is often increased, but most of this insulin appears to be bound to protein and is not available for transport across the cell membrane and action of the cell. 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